Functional Impairment of Mouse and Human Dendritic Cells Following Systemic Inflammatory Response Syndrome (Sirs): Towards Novel Diagnostics and Treatments

From Cell Death and Activation to Paralysis: Dysregulated Conventional Dendritic Cells in SIRS, Sepsis and Major Trauma Promote Immunosuppression

M Ashayeripanah, A Roquilly, J Villadangos

2026-01-01

Conventional dendritic cells (cDC) are pivotal for initiating antigen-specific T-cell responses. Upon encountering pathogen- and d..

Protocol to study ex vivo T cell priming by conventional dendritic cells from the mouse spleen

M Ashayeripanah, JA Villadangos

2024-12-20

Conventional dendritic cells (cDC) are professional antigen-presenting cells able to prime naive T cells. Here, we present a proto..

Prior infection with unrelated neurotropic virus exacerbates influenza disease and impairs lung T cell responses

IJH Foo, BY Chua, EB Clemens, SY Chang, X Jia, HA McQuilten, AHY Yap, AF Cabug, M Ashayeripanah, HEG McWilliam, JA Villadangos, M Evrard, LK Mackay, LM Wakim, JK Fazakerley, K Kedzierska, L Kedzierski

2024-12-01

Immunity to infectious diseases is predominantly studied by measuring immune responses towards a single pathogen, although co-infe..

Constitutive Flt3 signaling impacts conventional dendritic cell function

KR Wilson, C Macri, JA Villadangos, JD Mintern

2024-07-01

The development of dendritic cells (DCs) depends on signaling via the FMS-like tyrosine kinase 3 (Flt3) receptor. How Flt3 signali..

Systemic inflammatory response syndrome triggered by blood-borne pathogens induces prolonged dendritic cell paralysis and immunosuppression

Mitra Ashayeripanah, Javier Vega-Ramos, Daniel Fernandez-Ruiz, Shirin Valikhani, Aaron TL Lun, Jason T White, Louise J Young, Atefeh Yaftiyan, Yifan Zhan, Linda Wakim, Irina Caminschi, Mireille H Lahoud, Andrew M Lew, Ken Shortman, Gordon K Smyth, William R Heath, Justine D Mintern, Antoine Roquilly, Jose A Villadangos

2024-02-27

Blood-borne pathogens can cause systemic inflammatory response syndrome (SIRS) followed by protracted, potentially lethal immunosu..

Intestinal microbe-derived metabolites instruct macrophages in the lungs

A Roquilly, JA Villadangos

2022-12-01

The bacillus Calmette–Guérin (BCG) vaccine induces homotypic protection against tuberculosis and, surprisingly, heterotypic protec..

Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86

H Liu, KR Wilson, AM Firth, C Macri, P Schriek, AB Blum, J Villar, S Wormald, M Shambrook, B Xu, HJ Lim, HEG McWilliam, AF Hill, LE Edgington-Mitchell, I Caminschi, MH Lahoud, E Segura, MJ Herold, JA Villadangos, JD Mintern

2022-12-01

The MARCH E3 ubiquitin (Ub) ligase MARCH1 regulates trafficking of major histocompatibility complex class II (MHC II) and CD86, mo..

Monocyte Signature Associated with Herpes Simplex Virus Reactivation and Neurological Recovery after Brain Injury

T Chaumette, R Cinotti, A Molle, P Solomon, L Castain, C Fourgeux, HEG McWilliam, B Misme-Aucouturier, A Broquet, C Jacqueline, M Vourc’h, D Fradin, C Bossard, L David, E Montassier, C Braudeau, R Josien, JA Villadangos, K Asehnoune, C Bressollette-Bodin

2022-08-01

Rationale: Brain injury induces systemic immunosuppression, increasing the risk of viral reactivations and altering neurological r..

Transfusion-Related Renal Dysfunction After Cardiac Surgery: The Role of Myeloid-Related Protein_14 in Neutrophil-Mediated Tubular Damage

M Vourc'h, A Roquilly, A Foucher, C Retiere, F Feuillet, S Devi, HEG McWilliam, C Braudeau, G Bourreille, A Hachani, D O'Kane, SN Mueller, J Ischia, JC Roussel, JC Rigal, R Josien, B Rozec, JA Villadangos, K Asehnoune

2022-07-01

Transfusion is a specific cause of acute kidney injury (AKI) after cardiac surgery. Whether there is an association between the co..

Spatiotemporal Adaptations of Macrophage and Dendritic Cell Development and Function

A Roquilly, JD Mintern, JA Villadangos

2022-01-01

Macrophages and conventional dendritic cells (cDCs) are distributed throughout the body, maintaining tissue homeostasis and tolera..

MHC class II ubiquitination regulates dendritic cell function and immunity

KR Wilson, D Jenika, AB Blum, C Macri, B Xu, H Liu, P Schriek, D Schienstock, L Francis, FV Makota, S Ishido, SN Mueller, MH Lahoud, I Caminschi, LE Edgington-Mitchell, JA Villadangos, JD Mintern

2021-11-01

MHC class II (MHC II) Ag presentation by dendritic cells (DCs) is critical for CD4⁺ T cell immunity. Cell surface level..

Regulation of dendritic cell function by Fc-γ-receptors and the neonatal Fc receptor

C Macri, H Morgan, JA Villadangos, JD Mintern

2021-11-01

Dendritic cells (DCs) express receptors to sense pathogens and/or tissue damage and to communicate with other immune cells. Among ..

Dendritic cell Flt3 – regulation, roles and repercussions for immunotherapy

KR Wilson, JA Villadangos, JD Mintern

2021-10-01

Dendritic cells (DCs) are essential for initiating immune responses. Depending on the environment, the type of DC and the way in w..

Type 1 conventional dendritic cell fate and function are controlled by DC-SCRIPT

S Zhang, HD Coughlan, M Ashayeripanah, S Seizova, AJ Kueh, DV Brown, W Cao, N Jacquelot, A D'Amico, AM Lew, Y Zhan, CJ Tonkin, JA Villadangos, GK Smyth, M Chopin, SL Nutt

2021-04-01

The functional diversification of dendritic cells (DCs) is a key step in establishing protective immune responses. Despite the imp..

Ubiquitination of MHC Class II Is Required for Development of Regulatory but Not Conventional CD4 T Cells

H Liu, KR Wilson, P Schriek, C Macri, AB Blum, L Francis, M Heinlein, C Nataraja, J Harris, SA Jones, DHD Gray, JA Villadangos, JD Mintern

2020-09-01

MHC class II (MHC II) displays peptides at the cell surface, a process critical for CD4+ T cell development and priming. Ubiquitin..

A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver TRM Cell-Mediated Immunity against Malaria in Mice

AM Valencia-Hernandez, WY Ng, N Ghazanfari, S Ghilas, MN de Menezes, LE Holz, C Huang, K English, M Naung, PS Tan, KM Tullett, TM Steiner, MH Enders, L Beattie, YC Chua, CM Jones, A Cozijnsen, V Mollard, Y Cai, DG Bowen

2020-06-10

Liver-resident memory CD8⁺ T (T<inf>RM</inf>) cells remain in and constantly patrol the liver to elicit rapid immunity ..

Downregulation of MHC class I expression by influenza A and B viruses

M Koutsakos, HEG McWilliam, TE Aktepe, S Fritzlar, PT Illing, NA Mifsud, AW Purcell, S Rockman, PC Reading, JP Vivian, J Rossjohn, AG Brooks, JM Mackenzie, JD Mintern, JA Villadangos, THO Nguyen, K Kedzierska

2019-01-01

Manipulation of the MHC-I presentation pathway, and thus limiting MHC-I cell surface expression, is used by many viruses to evade ..